Publications

Rajkumar Misra, Abhijith Saseendran, Gijo George, Kuruva Veeresh, K Muruga Poopathi Raja, Srinivasarao Raghothama, Hans-Joerg Hofmann, Hosahudya N Gopi

Chemistry: A European Journal, vol. 23(15), 2017 Feb 13, pp. 3764-3772

Helices with additional H-bonds: crystallographic conformations of α,γ-hybrid peptides helices composed of β-hydroxy γ-amino acids (statines).

Ankita Malik, Mothukuri Ganesh Kumar, Anupam Bandyopadhyay, Hosahudya N. Gopi

Biopolymers, vol. 108(1), 2017 1

Exploring structural features of folded peptide architectures in the construction of nanomaterials

Rajkumar Misra, Rahi M. Reja, Lagumaddepalli V. Narendra, Gijo George, Srinivasarao Raghothama, Hosahudya N. Gopi

Chemical Communications, vol. 52(61), 2016 Jun 21, pp. 9597-9600

Non-classical Helices with cis Carbon-Carbon Double Bonds in the Backbone: Structural Features of α,γ-Hybrid Peptide Foldamers.

Mothukuri Ganesh Kumar, Varsha J. Thombare, Mona M. Katariya, Kuruva Veeresh, K. Muruga Poopathi Raja, Hosahudya N. Gopi

Angewandte Chemie, vol. 55(27), 2016 May 27, pp. 7847-7851

Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

Anupam Bandyopadhyay, Rajkumar Misra, Hosahudya N. Gopi

Chemical Communications, vol. 52(27), 2016 Feb 24, pp. 4938-4941

pH sensitive coiled coils: a strategy for enhanced liposomal drug delivery.

Rahi M. Reja, Mohsina Khan, Sumeet K. Singh, Rajkumar Misra, Anjali Shiras, Hosahudya N. Gopi

Nanoscale, vol. 8(9), 2016 Jan 25, pp. 5139-5145

γ- and β-Peptide Foldamers from Common Multifaceted Building Blocks: Synthesis and Structural Characterization.

Mothukuri Ganesh Kumar, Hosahudya N. Gopi

Organic Letters, vol. 17(19), 2015 Aug 16, pp. 4738-4741

Engineering polypeptide folding through trans double bonds: transformation of miniature β-meanders to hybrid helices

Mothukuri Ganesh Kumar, Sushil N. Benke, K. Muruga Poopathi Raja, Hosahudya N. Gopi

Chemical Communications, vol. 51(69), 2015 Jul 13, pp. 13397-13399

Design of stable β-hairpin mimetics through backbone disulfide bonds.

Mothukuri Ganesh Kumar, Sachitanand M. Mali, K. Muruga Poopathi Raja, Hosahudya N. Gopi

Organic Letters, vol. 17(2), 2015 16, pp. 230-233

Synthesis of Tetrasubstituted Symmetrical Pyrazines from β-Keto γ-Amino Esters: A Mild Strategy for Self-Dimerization of Peptides

Mothukuri Ganesh Kumar, Varsha J. Thombare, Rupal D. Bhaisare, Anindita Adak, Hosahudya N. Gopi

European Journal of Organic Chemistry, vol. 2015(1), 2015 1, pp. 135-141

Thioacetic acid/NaSH-mediated synthesis of N-protected amino thioacids and their utility in peptide synthesis

Sachitanand M Mali, Hosahudya N Gopi

The Journal of organic chemistry, vol. 79, ACS Publications, 2014, pp. 2377--2383

Foldamers to Nanotubes: Influence of Amino Acid Side Chains in the Hierarchical Assembly of α,γ4‐Hybrid Peptide Helices

Sandip V. Jadhav, Rajkumar Misra, Hosahudya N. Gopi

Chemistry: A European Journal, vol. 20(50), 2014 Nov 8, pp. 16523-16528

HBTU mediated 1-hydroxybenzotriazole (HOBt) conjugate addition: synthesis and stereochemical analysis of β-benzotriazole N-oxide substituted γ-amino acids and hybrid peptides

Sachitanand M. Mali, Mothukuri Ganesh Kumar, Mona M. Katariya, Hosahudya N. Gopi

Organic and Biomolecular Chemistry, vol. 12(42), 2014 Sep 9, pp. 8462-8472

Exploring β-Hydroxy γ-Amino Acids (Statines) in the Design of Hybrid Peptide Foldamers

Anupam Bandyopadhyay, Ankita Malik, Mothukuri Ganesh Kumar, Hosahudya N. Gopi

Organic Letters, vol. 16(1), 2014 3, pp. 294-297

Protein secondary structure mimetics: crystal conformations of α/γ 4-hybrid peptide12-helices with proteinogenic side chains and their analogy with α-and β-peptide helices

Sandip V Jadhav, Anupam Bandyopadhyay, Hosahudya N Gopi

Organic \& biomolecular chemistry, vol. 11, Royal Society of Chemistry, 2013, pp. 509--514

Remarkable thermoresponsive nanofibers from γ-peptides

Sandip V Jadhav, Hosahudya N Gopi

Chemical Communications, vol. 49, Royal Society of Chemistry, 2013, pp. 9179--9181

Efficient access to enantiopure γ4‐amino acids with proteinogenic side‐chains and structural investigation of γ4‐Asn and γ4‐Ser in hybrid peptide helices

Sandip V Jadhav, Rajkumar Misra, Sumeet K Singh, Hosahudya N Gopi

Chemistry--A European Journal, vol. 19, Wiley Online Library, 2013, pp. 16256--16262

γ-Amino acid mutated α-coiled coils as mild thermal triggers for liposome delivery

Sandip V Jadhav, Sumeet K Singh, Rahi M Reja, Hosahudya N Gopi

Chemical Communications, vol. 49, Royal Society of Chemistry, 2013, pp. 11065--11067

Thioacids mediated selective and mild N-acylation of amines

Sachitanand M Mali, Rupal D Bhaisare, Hosahudya N Gopi

The Journal of organic chemistry, vol. 78, ACS Publications, 2013, pp. 5550--5555

Self-assembly to function: design, synthesis, and broad spectrum antimicrobial properties of short hybrid E-vinylogous lipopeptides

S Shiva Shankar, Sushil N Benke, Narem Nagendra, Prabhakar Lal Srivastava, Hirekodathakallu V Thulasiram, Hosahudya N Gopi

Journal of medicinal chemistry, vol. 56, ACS Publications, 2013, pp. 8468--8474

A Designed Three‐Stranded β‐Sheet in an α/β Hybrid Peptide

Rajesh Sonti, Hosahudya N Gopi, Umashankara Muddegowda, Srinivasarao Ragothama, Padmanabhan Balaram

Chemistry--A European Journal, vol. 19, Wiley Online Library, 2013, pp. 5955--5965

Efficient access to enantiopure γ4-amino acids with proteinogenic side-chains and structural investigation of γ4-Asn and γ4-Ser in hybrid peptide helices.

Sandip V. Jadhav, Rajkumar Misra, Sumeet K. Singh, Hosahudya N. Gopi

Chemistry: A European Journal, vol. 19(48), 2013 Oct 25, pp. 16256-16262

Synthesis and stereochemical analysis of β-nitromethane substituted γ-amino acids and peptides

Mothukuri Ganesh Kumar, Sachitanand M. Mali, Hosahudya N. Gopi

Organic and Biomolecular Chemistry, vol. 11(5), 2013 2, pp. 803-813

α/γ 4-Hybrid peptide helices: synthesis, crystal conformations and analogy with the α-helix

Anupam Bandyopadhyay, Sandip V Jadhav, Hosahudya N Gopi

Chemical Communications, vol. 48, Royal Society of Chemistry, 2012, pp. 7170--7172

Copper (II) mediated facile and ultra fast peptide synthesis in methanol

Sachitanand M Mali, Sandip V Jadhav, Hosahudya N Gopi

Chemical communications, vol. 48, Royal Society of Chemistry, 2012, pp. 7085--7087

Thiazole--carbonyl interactions: A case study using phenylalanine thiazole cyclic tripeptides

Sachitanand M Mali, Tobias F Schneider, Anupam Bandyopadhyay, Sandip V Jadhav, Daniel B Werz, Hosahudya N Gopi

Crystal growth \& design, vol. 12, ACS Publications, 2012, pp. 5643--5648

Antiviral breadth and combination potential of peptide triazole HIV-1 entry inhibitors

Karyn McFadden, Patricia Fletcher, Fiorella Rossi, Kantharaju, Muddagowda Umashankara, Vanessa Pirrone, Srivats Rajagopal, Hosahudya Gopi, Fred C Krebs, Julio Martin-Garcia, others

Antimicrobial agents and chemotherapy, vol. 56, Am Soc Microbiol, 2012, pp. 1073--1080

Hybrid Peptides: Direct Transformation of α/α, β-Unsaturated γ-Hybrid Peptides to α/γ-Hybrid Peptide 12-Helices

Anupam Bandyopadhyay, Hosahudya N. Gopi

Organic Letters, vol. 14(11), 2012 Apr 18, pp. 2770-2773

A Facile Transformation of Amino Acids to Functionalized Coumarins.

Anupam Bandyopadhyay, Hosahudya N. Gopi

ChemInform, vol. 43(18), 2012 Apr 1

Synthesis of α,β‐Unsaturated γ‐Amino Esters with Unprecedented High (E)‐Stereoselectivity and Their Conformational Analysis in Peptides.

Sachitanand M. Mali, Anupam Bandyopadhyay, Sandip V. Jadhav, Mothukuri Ganesh Kumar, Hosahudya N. Gopi

ChemInform, vol. 43(7), 2012 Jan 14

Synthesis and structural investigations of functionalizable hybrid β-hairpin

Anupam Bandyopadhyay, Sachitanand M Mali, Pooja Lunawat, K Muruga Poopathi Raja, Hosahudya N Gopi

Organic letters, vol. 13, ACS Publications, 2011, pp. 4482--4485

A facile synthesis and crystallographic analysis of N-protected β-amino alcohols and short peptaibols

Sandip V Jadhav, Anupam Bandyopadhyay, Sushil N Benke, Sachitanand M Mali, Hosahudya N Gopi

Organic \& biomolecular chemistry, vol. 9, Royal Society of Chemistry, 2011, pp. 4182--4187

A facile transformation of amino acids to functionalized coumarins

Anupam Bandyopadhyay, Hosahudya N. Gopi

Organic and Biomolecular Chemistry, vol. 9(23), 2011 Oct 10, pp. 8089-8095

Synthesis of α, β-unsaturated γ-amino esters with unprecedented high (E)-stereoselectivity and their conformational analysis in peptides

Sachitanand M. Mali, Anupam Bandyopadhyay, Sandip V. Jadhav, Mothukuri Ganesh Kumar, Hosahudya N. Gopi

Organic and Biomolecular Chemistry, vol. 9(19), 2011 Aug 9, pp. 6566-6574

Tin(II) Chloride Assisted Synthesis of N-Protected γ-Amino β-Keto Esters Through Semipinacol Rearrangement.

Anupam Bandyopadhyay, Neha Agrawal, Sachitanand M. Mali, Sandip V. Jadhav, Hosahudya N. Gopi

ChemInform, vol. 42(11), 2011 Feb 15

Tin(II) chloride assisted synthesis of N-protected γ-amino β-keto esters through semipinacol rearrangement.

Anupam Bandyopadhyay, Neha Agrawal, Sachitanand M. Mali, Sandip V. Jadhav, Hosahudya N. Gopi

Organic and Biomolecular Chemistry, vol. 8(21), 2010 Sep 13, pp. 4855-4860

Introducing metallocene into a triazole peptide conjugate reduces its off-rate and enhances its affinity and antiviral potency for HIV-1 gp120

Hosahudya Gopi, Simon Cocklin, Vanessa Pirrone, Karyn McFadden, Ferit Tuzer, Isaac Zentner, Sandya Ajith, Sabine Baxter, Navneet Jawanda, Fred C Krebs, others

Journal of Molecular Recognition: An Interdisciplinary Journal, vol. 22, Wiley Online Library, 2009, pp. 169--174

Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1

Hosahudya Gopi, M Umashankara, Vanessa Pirrone, Judith LaLonde, Navid Madani, Ferit Tuzer, Sabine Baxter, Isaac Zentner, Simon Cocklin, Navneet Jawanda, others

Journal of medicinal chemistry, vol. 51, ACS Publications, 2008, pp. 2638--2647

Structure-based rationale for interleukin 5 receptor antagonism

Tetsuya Ishino, Adrian E Harrington, Hosahudya Gopi, Irwin Chaiken

Current pharmaceutical design, vol. 14, Bentham Science Publishers, 2008, pp. 1231--1239

A recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions

Karyn McFadden, Simon Cocklin, Hosahudya Gopi, Sabine Baxter, Sandya Ajith, Naheed Mahmood, Robin Shattock, Irwin Chaiken

PROTEINS: Structure, Function, and Bioinformatics, vol. 67, Wiley Online Library, 2007, pp. 617--629

Broad-Spectrum Anti-Human Immunodeficiency Virus (HIV) Potential of a Peptide HIV Type 1 Entry Inhibitor

Simon Cocklin, Hosahudya Gopi, Bianca Querido, Manideepthi Nimmagadda, Syna Kuriakose, Claudia Cicala, Sandya Ajith, Sabine Baxter, James Arthos, Julio Martín-García, Irwin M. Chaiken

Journal of Virology, vol. 81(7), 2007 Mar 1, pp. 3645-3648

Click chemistry on azidoproline: high-affinity dual antagonist for HIV-1 envelope glycoprotein gp120

Hosahudya N Gopi, Kalyan C Tirupula, Sabine Baxter, Sandya Ajith, Irwin M Chaiken, others

ChemMedChem, vol. 1, Citeseer, 2006, p. 54

Hybrid Peptide Hairpins Containing α‐and ω‐Amino Acids: Conformational Analysis of Decapeptides with Unsubstituted β‐, γ‐, and δ‐Residues at Positions 3 and 8

Rituparna S Roy, Hosahudya N Gopi, Srinivasarao Raghothama, Isabella L Karle, Padmanabhan Balaram

Chemistry--A European Journal, vol. 12, Wiley Online Library, 2006, pp. 3295--3302

Peptide hairpins with strand segments containing α‐and β‐amino acid residues: Cross‐strand aromatic interactions of facing Phe residues

Rituparna S Roy, Hosahudya N Gopi, Srinivasarao Raghothama, Richard D Gilardi, Isabella L Karle, Padmanabhan Balaram

Peptide Science: Original Research on Biomolecules, vol. 80, Wiley Online Library, 2005, pp. 787--799

An efficient synthesis of a probe for protein function: 2, 3-diaminopropionic acid with orthogonal protecting groups

Ethan A Englund, Hosahudya N Gopi, Daniel H Appella

Organic Letters, vol. 6, ACS Publications, 2004, pp. 213--215

Proteolytic stability of β-peptide bonds probed using quenched fluorescent substrates incorporating a hemoglobin cleavage site

Hosahudya N Gopi, Gudihal Ravindra, Prajna P Pal, Priyaranjan Pattanaik, Hemalatha Balaram, Padmanabhan Balaram

FEBS letters, vol. 535, Elsevier, 2003, pp. 175--178

Crystal structure of a hydrophobic 19-residue peptide helix containing three centrally located D amino acids

Isabella L Karle, Hosahudya N Gopi, Padmanabhan Balaram

Proceedings of the National Academy of Sciences, vol. 100, National Acad Sciences, 2003, pp. 13946--13951

Stage-specific profiling of Plasmodium falciparum proteases using an internally quenched multispecificity protease substrate

Priyaranjan Pattanaik, Bimba Jain, Gudihal Ravindra, Hosahudya N Gopi, Prajna P Pal, Hemalatha Balaram, Padmanabhan Balaram

Biochemical and biophysical research communications, vol. 309, Elsevier, 2003, pp. 974--979

An almost ideal 19-residue alpha-helix that accommodates three D-residues in the sequence

I Karle, HN Gopi, P Balaram

2003 1

A crystalline β-hairpin peptide nucleated by a type I’ Aib-DAla β-turn: Evidence for cross strand aromatic interactions

Subrayashastry Aravinda, Narayanaswamy Shamala, Rai Rajkishore, Hosahudya N Gopi, Padmanabhan Balaram

Angewandte Chemie, vol. 114, Wiley Online Library, 2002, pp. 4019--4021

β-Hairpins generated from hybrid peptide sequences containing both α- and β-amino acids

Hosahudya N Gopi, Rituparna S Roy, Srinivasa R Raghothama, Isabella L Karle, Padmanabhan Balaram

Helvetica chimica acta, vol. 85, Wiley Online Library, 2002, pp. 3313--3330

Infinite pleated β-sheet formed by the β-hairpin Boc-βPhe-βPhe-DPro-Gly-βPhe-βPhe-OMe

Isabella Karle, Hosahudya N Gopi, Padmanabhan Balaram

Proceedings of the National Academy of Sciences, vol. 99, National Acad Sciences, 2002, pp. 5160--5164

Synthesis of alkyl and aryl esters of N-protected beta-homoamino acids from N-protected alpha-aminodiazoketones

GR Vasanthakumar, HN Gopi, V Babu

Protein and peptide letters, vol. 9, Bentham Science Publishers, 2002, pp. 529--532

Peptide hybrids containing α- and β-amino acids: Structure of a decapeptide β-hairpin with two facing β-phenylalanine residues

Isabella L Karle, Hosahudya N Gopi, Padmanabhan Balaram

Proceedings of the National Academy of Sciences, vol. 98, National Acad Sciences, 2001, pp. 3716--3719

Convenient and efficient synthesis of Boc-/ Z- / Fmoc-β-amino acids employing protected α-amino acid fluorides

K Ananda, HN Gopi, VV Suresh Babu

The Journal of Peptide Research, vol. 55, Wiley Online Library, 2000, pp. 289--294

Synthesis of Boc-and Z-protected amino acid fluorides employing DAST as a fluorinating agent

VV Babu, HN Gopi, K Ananda

NISCAIR-CSIR, India, 2000

Wolff rearrangement of N-protected α-aminodiazoketones in presence of substituted phenol as a method for the synthesis of 2, 4, 5-trichlorophenyl esters of Fmoc- /Boc- /Z- β-homoamino acids

Hosahudya N Gopi, Kuppanna Ananda, Vommina V Suresh Babu

Protein \& Peptide Letters, vol. 7, Bentham Science Publishers, 2000, pp. 33--36

Convenient and simple homologation of Nα-urethane protected α-amino acids to their β-homologues with concomitant o-nitrophenyl ester formation

Hosahudya N Gopi, Vommina V Suresh Babu

Letters in Peptide Science, vol. 7, Springer, 2000, pp. 165--169

Zinc promoted simple synthesis of oligomer free Nα-Fmoc-amino acids using Fmoc -chloride as an acylating agent under neutral conditions

Hosahudya N Gopi, Vommina V Suresh Babu

The Journal of Peptide Research, vol. 55, Wiley Online Library, 2000, pp. 295--299

Convenient and simple homologation of N-alpha-urethane protected alpha-amino acids to their beta-homologues with concomitant pentafluorophenyl ester formation

H.N. Gopi, V.V. Sureshbabu

2000 1

Convenient and simple homologation of N(Î±)-urethane protected Î±-amino acids to their Î²-homologous with concomitant pentafluorophenyl ester formation

H.N. Gopi, V.V. Sureshbabu

2000 1

Synthesis of β-amino acids using Boc-/Z-amino acid pentafluorophenyl esters

Vommina V Suresh Babu, Hosahudya N Gopi

Letters in Peptide Science, vol. 6, Springer, 1999, pp. 173--178

Zinc promoted simple synthesis of Z-amino acids under neutral conditions

Hosahudya N Gopi, Kuppanna Ananda, VV Suresh Babu

Protein and Peptide Letters, vol. 6, BENTHAM SCIENCE PUBLISHERS BV, 1999, pp. 233--236

Fmoc-peptide acid chlorides in fragment coupling: Synthesis of β-casomorphin by 3+2 divergent approach

VV Suresh Babu, K Gayathri, HN Gopi

Synthetic communications, vol. 29, Taylor & Francis, 1999, pp. 79--91

Homologation of α-amino acids to β-amino acids using Fmoc-amino acid pentafluorophenyl esters

V.V. Sureshbabu, H.N. Gopi, K. Anandi

1999 1

Rapid and efficient synthesis of peptides containing α,α-dialkylamino acids employing KOBt

Kuppanna Ananda, Hosahudya N Gopi, Vommina V Suresh Babu

Letters in Peptide Science, vol. 5, Springer, 1998, pp. 277-284

Rapid and efficient synthesis of peptide fragments containing α-amino isobutyric acid using Fmoc-amino acid chlorides/potassium salt of 1-hydroxybenzotriazole

Vommina V Suresh Babu, Hosahudya N Gopi

Tetrahedron letters, vol. 39, Elsevier, 1998, pp. 1049--1050

Fmoc-peptide acid chlorides: Preparation, characterization and utility in peptide synthesis

K Gayathri, HN Gopi, VV Babu

NISCAIR-CSIR, India, 1998

Synthesis of [Leu5] enkephalin using Fmoc- amino acid chloride/KOAt

HN Gopi, VV Sureshbabu

Journal of the Indian Chemical Society, vol. 75, Indian Chemical Society, 1998, pp. 511--513

Synthesis of peptides employing Fmoc-amino acid chlorides and commercial zinc dust

Hosahydya N Gopi, Vommina V Suresh Babu

Tetrahedron letters, vol. 39, Elsevier, 1998, pp. 9769--9772

SYNTHESIS OF PEPTIDES MEDIATED BY POTASSIUM SALT OF 1-HYDROXY-7-AZABENZOTRIAZOLE

H.N. Gopi, V.V. Sureshbabu

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, vol. 37(4), 1998 1, pp. 394-396

Patents

Inhibition of HIV-1 Infection by Potent Metallocene Conjugated Peptide Through Conformational Entrapment of Envelope GP120

Hosahudya N. Gopi, Irwin M. Chaiken

2015 Jan 8

Dual inhibitors of HIV-1 gp-120 interactions

Hosahudya Gopi, Irwin Chaiken

2012 Jan 10

Publications

Patents

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